Edgar Castillo and Tigres will look for a road win at Chivas while Marco Vidal and Indios will hope to get on the scoreboard when they travel to Santos.
Chivas - Tigres
Edgar Castillo and Tigres travel to Guadalajara on Saturday to take on Chivas at Estadio Jalisco.
Tigres head coach Daniel Guzman is expected to give Edgar Castillo the start at left back.
The visitors are coming off of a disappointing home draw against Puebla which saw them fail to take advantage of being one man up for the final 35 minutes.
Guzman will rely on last week's goal scorer, Lucas Lobos, to front the Tigres attack while Castillo and Mexican international José Antonio Castro will solidify a stingy defense that welcomes back Castro from Gold Cup duty.
Chivas comes in with a high-flying offense that put three goals on the scoreboard against Toluca last weekend but still lost by a goal.
Head coach Paco Ramirez will gladly welcome back midfielder Alberto Medina and defender Jonny Magallón following their triumphant Gold Cup title to help close the holes on defense.
Guzman's squad has no major injuries however Argentinean forward Gaston Fernandez is suspended for Saturday's encounter while Ramirez will be without Omar Arellano due to injury and Hector Reynoso because of suspension.
Santos - Indios
Marco Vidal and Indios travel to nearby Coahuila on Sunday to take on Santos at Estadio Corona in Torreon.
Vidal is liley to get the starting nod in the Indios midfield for Uruguayan head coach Hector Eugui.
Both clubs will be on the search for their first win of the 2009 Apertura after the Aborigenes drew last week with Monterrey and the Guerreros split the points at Morelia.
A road victory will help ease alot of early relegation worries for Eugui's club who find themselves in 11th place in Mexico's complicated relegation table which is based on a percentage of goal scored in games played in the last three season.
Vidal and company will have to do better on the offensive end to help avoid another situation where goalkeeper Cesar Lozano is the best player on the field for Indios.
Santos are directed by Sergio Bueno who will rely on Argentinean midfielder Daniel Ludueña and forward Carlos Ochoa to spearhead an attack that will try to impress the home fans.
Bueno's offensive strategy will be mildly affected by the absence of forward Agustín Herrera who is injured while Eugui will have the luxury of a full squad against their northern neighbors.
Paco Torres is doubtful to see any playing time after sitting on the bench in Pachuca's last two matches.