Jose Francisco Torres and Pachuca downed America at home while Michael Orozco was sent off as San Luis coughed up two points in Toluca.
Pachuca 2 - 1 America
Francisco Torres got the start and went 70 minutes as he and los Tuzos have come to within two points of third place in their group.
Pachuca got the scoring started. In the 22nd minute, Argentine international Christian Gimenez hit a free kick from the top left corner of the 18-yard box, up and over the wall, into the near side of net.
Los Tuzos increased their lead in the second half in the 85th minute when Damian Alvarez dashed into the bottom left corner of the area and sent a well-placed cross into the six-yard box to the awaiting Juan Carlos Cacho whose header found the back of the net.
America would narrow the lead in the ninetieth minute when Paraguay international Salvador Cabanas hit a beautiful free kick from 30 yards out, leaving Columbian goalkeeper Miguel Calero was stuck in his boots.
Next week, Pachuca travel to Morelia, who currently sit in second place, while America will host Puebla who have only dropped one game this Apertura.
Toluca 1 - 1 San Luis
Michael Orozco and the Gladiadores of San Luis were minutes away from pulling off an upset in the belly of the beast in Toluca on a day when all the goals were scored via the penalty spot.
In the 24th minute, San Luis' Argentine forward Alfredo Moreno brilliantly dribbled between two Red Devil defenders into the top of the 18-yard box, only to be taken down. Referee Jose Alfredo did not hesitate to call a penalty, which Moreno duly converted.
Orozco, who started at center back, was red carded in the 69th minute for stepping on Hector Raul Mancilla and the man disadvantage came back to bite the visitors late.
Three minutes short of stoppage time, a phantom foul was called in the penalty area when Toluca defender Edgar Duenas found himself on top of the ball ten yards out in enemy territory. A swing and miss reassured him that he does not belong on offense, but Alfredo had pity and called for a penalty much to the confusion of the San Luis back line.
Mancilla converted the penalty on the second try after Gladiador goalkeeper Adrian Martinez had blocked the first, but was flagged for coming out too far off his line.
Next week, San Luis will host struggling Atlante while Toluca will host Edgar Castillo and los Tigres.
Edgar Castillo was out due to a thigh injury suffered during the week as Tigres ended a six game winless streak by topping mighty Cruz Azul at home, 2 - 0.
Marco Vidal rode the pine as the Indios lost to Queretaro 3-1, extending their winless streak to 11 weeks.