Herculez Gomez scored again for Pachuca but it was not enough to overcome Tigres while Edgar Castillo received a rare start in Puebla's humiliating loss in Torreon to Santos.
Tigres 4 - 2 Pachuca
Herculez Gomez scored his third goal in two games but it was not nearly enough against Jonathan Bornstein's Tigres on Wednesday evening at Estadio Universitario in Monterrey.
Gomez entered the match in the 66th minute and scored in second half stoppage time for the Tuzos.
Teammate and compatriot Jose Francisco Torres was unavailable for the contest due to suspension.
Jonathan Bornstein saw action for the first time in months for Tigres coming on in the 87th minute.
Pachuca scored the game's first goal off of a superb effort in the 38th minute by Pachuca's Franco Faustino Arizala who used his head to control a cross from the right side before outracing the Tigres defense and beating Tigres goalkeeper Enrique Palos with a shot.
But just two minutes before the break, the hosts equalized when Israel Jimenez centered to Hector Mancilla who smacked a header past Pachuca's backup goalkeeper Rodolfo Cota.
The match was then turned on its head in the 56th minute when Arizala foolishly stomped on Tigres' Danilinho earning a straight red card.
It took just two minutes for the Felinos to take advantage through another Mancilla goal when he took Danilinho's cross and fired in a shot from long-range that banked off the post and in.
Twelve minutes later Mancilla elected to be the playmaker setting up Lucas Lobos with an easy tap-in from close range.
Tigres effectively put the match away in the 89th minute when Alan Pulido outraced Cota to a loose ball and scored.
Gomez's goal came shortly after that when he took advantage of a lapse in the Tigres defense and beat Palos one-on-one to make the scoreline a bit more respectable.
Pachuca will try to get back on the winning track this Saturday at home versus Atlante.
Santos 4 - 0 Puebla
Edgar Castillo received a rare start on Wednesday for Puebla who were drilled by Santos on the road at Estadio Corona in Torreon.
Castillo started in defense after his weekend goal-scoring heroics but his insertion did very little to stop a Santos squad that completely overwhelmed Puebla all evening long.
Daniel Emmanuel Luduena scored the first of his two goals in the 16th minute when he took Oribe Peralta's pass and fired in past Puebla goalkeeper Edgar Hernandez.
Luduena scored again in the 35th this time making a terrific solo run in the area and sending a left-footed shot past Hernandez.
Santos stretched the lead to three in the 59th minute when Christian Benitez scored on Rafael Alejandro Figueroa's cross.
The hosts then put the match away seven minutes later with Jaime Toldeo's long-range effort that beat Hernandez.
Puebla will next host Cruz Azul on Saturday.
Neither Daniel Antunez nor Sammy Ochoa featured in Estudiantes' 2-2 draw at Necaxa.